Drug interactions
Insulin glulisine + Olanzapine
Severity: Moderate
Insulin glulisine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can raise blood glucose through insulin resistance and weight gain, working against insulin glulisine. Mealtime insulin doses may need to be increased.
What this interaction means in plain words
Insulin glulisine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin glulisine belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Olanzapine induces insulin resistance and impaired glucose regulation, opposing insulin action.
What to do
Increase glucose monitoring around olanzapine initiation or dose changes and adjust insulin glulisine doses. Reassess if olanzapine is stopped because hypoglycemia risk may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin glulisine and Olanzapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Olanzapine
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Olanzapine?
MediHelp rates the interaction as moderate. Insulin glulisine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can raise blood glucose through insulin resistance and weight gain, working against insulin glulisine. Mealtime insulin doses may need to be increased.
How serious is the interaction between Insulin glulisine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase glucose monitoring around olanzapine initiation or dose changes and adjust insulin glulisine doses. Reassess if olanzapine is stopped because hypoglycemia risk may rise.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
