Drug interactions
Insulin glulisine + Salicylates
Severity: Moderate
Insulin glulisine and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Large doses of salicylates can lower blood glucose and potentiate insulin, leading to hypoglycemia. The effect is mainly seen at anti-inflammatory doses, not low-dose use.
What this interaction means in plain words
Insulin glulisine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose salicylates increase insulin secretion and peripheral glucose utilization, adding to insulin effect.
What to do
Monitor blood glucose more often when high-dose salicylates are started or stopped, and reduce the insulin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Salicylates?
MediHelp rates the interaction as moderate. Insulin glulisine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Large doses of salicylates can lower blood glucose and potentiate insulin, leading to hypoglycemia. The effect is mainly seen at anti-inflammatory doses, not low-dose use.
How serious is the interaction between Insulin glulisine and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when high-dose salicylates are started or stopped, and reduce the insulin dose if needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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