Drug interactions
Insulin glulisine + Salsalate
Severity: Moderate
Insulin glulisine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid and at higher doses can lower blood glucose. It may potentiate insulin glulisine and cause hypoglycemia.
What this interaction means in plain words
Insulin glulisine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate improves insulin sensitivity and may increase insulin secretion, giving an additive glucose-lowering effect.
What to do
Monitor blood glucose more often when salsalate is started or its dose is changed, and adjust the insulin glulisine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Salsalate?
MediHelp rates the interaction as moderate. Insulin glulisine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid and at higher doses can lower blood glucose. It may potentiate insulin glulisine and cause hypoglycemia.
How serious is the interaction between Insulin glulisine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when salsalate is started or its dose is changed, and adjust the insulin glulisine dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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