Drug interactions
Insulin glulisine + Sulfadiazine
Severity: Moderate
Insulin glulisine and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics have occasionally caused hypoglycemia, which may add to the effect of insulin. The risk is higher in renal impairment or poor nutrition.
What this interaction means in plain words
Insulin glulisine and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: sulfonamides may stimulate insulin secretion, adding to exogenous insulin effect.
What to do
Monitor blood glucose during sulfadiazine therapy and reduce the insulin glulisine dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin glulisine and Sulfadiazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Insulin glulisine with Sulfadiazine?
MediHelp rates the interaction as moderate. Insulin glulisine and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics have occasionally caused hypoglycemia, which may add to the effect of insulin. The risk is higher in renal impairment or poor nutrition.
How serious is the interaction between Insulin glulisine and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfadiazine therapy and reduce the insulin glulisine dose if hypoglycemia occurs.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
