Drug interactions
Insulin icodec + Octreotide
Severity: Moderate
Insulin icodec and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can either raise or lower blood glucose and change insulin needs unpredictably. With a long-acting weekly insulin, hypoglycemia may be prolonged.
What this interaction means in plain words
Insulin icodec and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin icodec belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin analogue effects on insulin, glucagon and growth hormone secretion alter glucose homeostasis.
What to do
Monitor blood glucose closely when starting, changing or stopping octreotide and adjust the insulin icodec dose accordingly. Use caution with dose increases given its long half-life.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin icodec
- Hydroxychloroquine + Insulin icodec Moderate
- Insulin icodec + Lanreotide Moderate
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin icodec with Octreotide?
MediHelp rates the interaction as moderate. Insulin icodec and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can either raise or lower blood glucose and change insulin needs unpredictably. With a long-acting weekly insulin, hypoglycemia may be prolonged.
How serious is the interaction between Insulin icodec and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, changing or stopping octreotide and adjust the insulin icodec dose accordingly. Use caution with dose increases given its long half-life.
What other medicines interact with Insulin icodec?
MediHelp also lists interactions of Insulin icodec with, for example, Hydroxychloroquine, Lanreotide. The full list is on the Insulin icodec page.
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