Drug interactions
Insulin isophane protamine human + Magnesium salicylate
Severity: Moderate
Insulin isophane protamine human and Magnesium salicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At high doses, salicylates such as magnesium salicylate can lower blood glucose and potentiate insulin, raising the risk of hypoglycemia. The effect is chiefly seen at anti-inflammatory doses.
What this interaction means in plain words
Insulin isophane protamine human and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
High-dose salicylates increase insulin secretion and peripheral glucose utilization, adding to insulin effect.
What to do
Monitor blood glucose more frequently when high-dose magnesium salicylate is started or stopped, and adjust the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin isophane protamine human and Magnesium salicylate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Magnesium salicylate?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At high doses, salicylates such as magnesium salicylate can lower blood glucose and potentiate insulin, raising the risk of hypoglycemia. The effect is chiefly seen at anti-inflammatory doses.
How serious is the interaction between Insulin isophane protamine human and Magnesium salicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when high-dose magnesium salicylate is started or stopped, and adjust the insulin dose accordingly.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
