Drug interactions
Insulin isophane protamine human + Octreotide
Severity: Moderate
Insulin isophane protamine human and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia in insulin-treated patients. Insulin requirements often fall, particularly in type 1 diabetes.
What this interaction means in plain words
Insulin isophane protamine human and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Octreotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism inhibits secretion of insulin and counter-regulatory hormones, altering glucose balance.
What to do
Monitor glucose frequently when starting or changing octreotide and adjust the insulin dose accordingly, with particular attention to hypoglycemia in type 1 diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Octreotide
Frequently asked questions
Can I take Insulin isophane protamine human with Octreotide?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide suppresses insulin, glucagon and growth hormone secretion, so it can cause either hypoglycemia or hyperglycemia in insulin-treated patients. Insulin requirements often fall, particularly in type 1 diabetes.
How serious is the interaction between Insulin isophane protamine human and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when starting or changing octreotide and adjust the insulin dose accordingly, with particular attention to hypoglycemia in type 1 diabetes.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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