Drug interactions
Insulin isophane protamine human + Olmesartan
Severity: Minor
Insulin isophane protamine human and Olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity and occasionally enhance insulin's glucose-lowering effect, leading to hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Insulin isophane protamine human and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Insulin isophane protamine human belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Probable improved insulin sensitivity with angiotensin receptor blockade; mechanism not firmly established.
What to do
Monitor blood glucose after starting or changing olmesartan and adjust the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Insulin isophane protamine human with Olmesartan?
MediHelp rates the interaction as minor. Insulin isophane protamine human and Olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may improve insulin sensitivity and occasionally enhance insulin's glucose-lowering effect, leading to hypoglycemia. The effect is usually modest.
How serious is the interaction between Insulin isophane protamine human and Olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing olmesartan and adjust the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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