Drug interactions
Insulin isophane protamine human + Sacubitril / valsartan
Severity: Minor
Insulin isophane protamine human and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may improve insulin sensitivity, which can increase the glucose-lowering effect of insulin. Hypoglycemia may occur, mainly early in treatment.
What this interaction means in plain words
Insulin isophane protamine human and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible enhancement of insulin sensitivity through angiotensin II receptor blockade.
What to do
Monitor blood glucose when starting sacubitril/valsartan and reduce the insulin dose if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Insulin isophane protamine human and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may improve insulin sensitivity, which can increase the glucose-lowering effect of insulin. Hypoglycemia may occur, mainly early in treatment.
How serious is the interaction between Insulin isophane protamine human and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting sacubitril/valsartan and reduce the insulin dose if hypoglycemia develops.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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