Drug interactions
Insulin isophane protamine human + Somatropin
Severity: Moderate
Insulin isophane protamine human and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin induces insulin resistance and can raise blood glucose, reducing the effectiveness of insulin. Patients with diabetes may need higher insulin doses after starting growth hormone, particularly at higher somatropin doses.
What this interaction means in plain words
Insulin isophane protamine human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin isophane protamine human belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Growth hormone antagonizes insulin action by reducing peripheral glucose uptake and increasing lipolysis and hepatic glucose output.
What to do
Monitor blood glucose closely after starting or adjusting somatropin and increase insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Somatropin?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin induces insulin resistance and can raise blood glucose, reducing the effectiveness of insulin. Patients with diabetes may need higher insulin doses after starting growth hormone, particularly at higher somatropin doses.
How serious is the interaction between Insulin isophane protamine human and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely after starting or adjusting somatropin and increase insulin dose as needed.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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