Drug interactions
Insulin isophane protamine human + Sulfisoxazole
Severity: Moderate
Insulin isophane protamine human and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibiotics can occasionally cause hypoglycemia, and this may add to insulin effect. Risk is higher in renal impairment, malnutrition or older patients.
What this interaction means in plain words
Insulin isophane protamine human and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfonamides may stimulate insulin secretion, and the mechanism with exogenous insulin is additive glucose lowering.
What to do
Monitor blood glucose during sulfisoxazole therapy and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin isophane protamine human
- Ethanol + Insulin isophane protamine human Major
- Insulin isophane protamine human + Pioglitazone Major
- Insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin isophane protamine human Moderate
- Albiglutide + Insulin isophane protamine human Moderate
- Alogliptin + Insulin isophane protamine human Moderate
Frequently asked questions
Can I take Insulin isophane protamine human with Sulfisoxazole?
MediHelp rates the interaction as moderate. Insulin isophane protamine human and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibiotics can occasionally cause hypoglycemia, and this may add to insulin effect. Risk is higher in renal impairment, malnutrition or older patients.
How serious is the interaction between Insulin isophane protamine human and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during sulfisoxazole therapy and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Insulin isophane protamine human?
MediHelp also lists interactions of Insulin isophane protamine human with, for example, Ethanol, Pioglitazone, Rosiglitazone. The full list is on the Insulin isophane protamine human page.
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