Drug interactions
Insulin lispro + Metformin-repaglinide
Severity: Moderate
Insulin lispro and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin lispro taken with metformin and repaglinide adds to the glucose-lowering effect of the combination. Hypoglycemia may occur, especially if meals are skipped or doses are not adjusted.
What this interaction means in plain words
Insulin lispro and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects of exogenous insulin, repaglinide-stimulated insulin secretion and metformin's reduction of hepatic glucose output.
What to do
Monitor blood glucose frequently when starting or changing doses and lower the insulin or repaglinide dose if hypoglycemia occurs. Advise the patient to take mealtime agents only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Insulin lispro
Frequently asked questions
Can I take Insulin lispro with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Insulin lispro and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin lispro taken with metformin and repaglinide adds to the glucose-lowering effect of the combination. Hypoglycemia may occur, especially if meals are skipped or doses are not adjusted.
How serious is the interaction between Insulin lispro and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or changing doses and lower the insulin or repaglinide dose if hypoglycemia occurs. Advise the patient to take mealtime agents only with meals.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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