Drug interactions
Insulin lispro + Nateglinide
Severity: Moderate
Insulin lispro and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates endogenous insulin release and, with injected insulin, can lead to additive hypoglycemia. The risk is highest when meals are delayed or skipped.
What this interaction means in plain words
Insulin lispro and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from meglitinide-stimulated insulin secretion and exogenous insulin.
What to do
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Instruct the patient to take nateglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin lispro with Nateglinide?
MediHelp rates the interaction as moderate. Insulin lispro and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates endogenous insulin release and, with injected insulin, can lead to additive hypoglycemia. The risk is highest when meals are delayed or skipped.
How serious is the interaction between Insulin lispro and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs. Instruct the patient to take nateglinide only with meals.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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