Drug interactions
Insulin lispro + Pasireotide
Severity: Moderate
Insulin lispro and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide often causes hyperglycemia by suppressing insulin and incretin secretion. Patients on insulin may need higher doses.
What this interaction means in plain words
Insulin lispro and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin lispro belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor activation reduces insulin and incretin secretion, causing hyperglycemia that opposes insulin.
What to do
Monitor glucose frequently when starting pasireotide and increase the insulin dose as needed. Adjust again if pasireotide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin lispro with Pasireotide?
MediHelp rates the interaction as moderate. Insulin lispro and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide often causes hyperglycemia by suppressing insulin and incretin secretion. Patients on insulin may need higher doses.
How serious is the interaction between Insulin lispro and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when starting pasireotide and increase the insulin dose as needed. Adjust again if pasireotide is stopped.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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