Drug interactions
Insulin neutral human + Phenelzine
Severity: Moderate
Insulin neutral human and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine, a non-selective MAO inhibitor, can lower blood glucose and potentiate the effect of insulin. This can cause unexpected or prolonged hypoglycemia.
What this interaction means in plain words
Insulin neutral human and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
The mechanism is not fully established; MAO inhibitors may enhance insulin secretion or sensitivity and impair counter-regulatory responses.
What to do
Monitor blood glucose frequently when phenelzine is started, changed or stopped, and reduce the insulin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Insulin neutral human with Phenelzine?
MediHelp rates the interaction as moderate. Insulin neutral human and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine, a non-selective MAO inhibitor, can lower blood glucose and potentiate the effect of insulin. This can cause unexpected or prolonged hypoglycemia.
How serious is the interaction between Insulin neutral human and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when phenelzine is started, changed or stopped, and reduce the insulin dose if needed.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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