Drug interactions
Insulin neutral human + Selegiline
Severity: Moderate
Insulin neutral human and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors including selegiline may enhance the hypoglycemic effect of insulin. Unexpected hypoglycemia may occur, particularly with non-selective or higher doses.
What this interaction means in plain words
Insulin neutral human and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not well established; MAO inhibition may increase insulin sensitivity or secretion.
What to do
Monitor blood glucose when selegiline is started or changed, and lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Insulin neutral human with Selegiline?
MediHelp rates the interaction as moderate. Insulin neutral human and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors including selegiline may enhance the hypoglycemic effect of insulin. Unexpected hypoglycemia may occur, particularly with non-selective or higher doses.
How serious is the interaction between Insulin neutral human and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when selegiline is started or changed, and lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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