Drug interactions
Insulin neutral human-insulin isophane protamine human + Nateglinide
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide with insulin increases the risk of hypoglycemia, since both lower glucose by raising insulin availability. The combination is not commonly used.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive hypoglycemic effect of exogenous insulin and nateglinide-stimulated endogenous insulin release.
What to do
Monitor glucose closely and reduce the insulin dose if hypoglycemia occurs. Reassess whether both agents are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Nateglinide?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide with insulin increases the risk of hypoglycemia, since both lower glucose by raising insulin availability. The combination is not commonly used.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the insulin dose if hypoglycemia occurs. Reassess whether both agents are needed.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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