Drug interactions
Insulin neutral human-insulin isophane protamine human + Pioglitazone
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone improves insulin sensitivity, so adding it to insulin can lower glucose further and raise the risk of hypoglycemia. The combination also increases fluid retention and the risk of edema and heart failure.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
Additive glucose-lowering effect through insulin sensitization combined with exogenous insulin, and PPAR-gamma mediated fluid retention.
What to do
Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs when starting pioglitazone. Watch for weight gain, edema and heart failure symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Pioglitazone
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Pioglitazone?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone improves insulin sensitivity, so adding it to insulin can lower glucose further and raise the risk of hypoglycemia. The combination also increases fluid retention and the risk of edema and heart failure.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin dose if hypoglycemia occurs when starting pioglitazone. Watch for weight gain, edema and heart failure symptoms.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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