Drug interactions
Insulin neutral human-insulin isophane protamine human + Somapacitan
Severity: Moderate
Insulin neutral human-insulin isophane protamine human and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone analogs reduce insulin sensitivity, so glucose control can worsen after somapacitan is started or the dose is raised. Patients on insulin may need higher doses to stay in range.
What this interaction means in plain words
Insulin neutral human-insulin isophane protamine human and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin neutral human-insulin isophane protamine human belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: growth hormone induces insulin resistance and raises hepatic glucose output and lipolysis.
What to do
Monitor blood glucose more often when somapacitan is started or its dose changed, and titrate insulin upward as needed. Reduce insulin again if growth hormone is stopped or lowered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin neutral human-insulin isophane protamine human with Somapacitan?
MediHelp rates the interaction as moderate. Insulin neutral human-insulin isophane protamine human and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone analogs reduce insulin sensitivity, so glucose control can worsen after somapacitan is started or the dose is raised. Patients on insulin may need higher doses to stay in range.
How serious is the interaction between Insulin neutral human-insulin isophane protamine human and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when somapacitan is started or its dose changed, and titrate insulin upward as needed. Reduce insulin again if growth hormone is stopped or lowered.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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