Drug interactions
Insulin nph + Rasagiline
Severity: Moderate
Insulin nph and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors have been reported to enhance the blood glucose lowering effect of insulin and other antidiabetic drugs. This may increase the risk of hypoglycemia, particularly when starting or stopping the MAO inhibitor.
What this interaction means in plain words
Insulin nph and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; MAO inhibition may enhance insulin sensitivity or alter glucose counter-regulation.
What to do
Monitor blood glucose more frequently when rasagiline is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Insulin nph with Rasagiline?
MediHelp rates the interaction as moderate. Insulin nph and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors have been reported to enhance the blood glucose lowering effect of insulin and other antidiabetic drugs. This may increase the risk of hypoglycemia, particularly when starting or stopping the MAO inhibitor.
How serious is the interaction between Insulin nph and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when rasagiline is started, changed or stopped. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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