Drug interactions
Insulin regular human + Selegiline
Severity: Moderate
Insulin regular human and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of insulin and may increase hypoglycemia risk. The effect with selective MAO-B inhibition at low doses is probably small.
What this interaction means in plain words
Insulin regular human and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may enhance insulin secretion or sensitivity and impair counter-regulatory responses; mechanism not fully established.
What to do
Monitor blood glucose more frequently when starting or stopping selegiline and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Insulin regular human with Selegiline?
MediHelp rates the interaction as moderate. Insulin regular human and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of insulin and may increase hypoglycemia risk. The effect with selective MAO-B inhibition at low doses is probably small.
How serious is the interaction between Insulin regular human and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or stopping selegiline and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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