Drug interactions
Iobenguane i + Isocarboxazid
Severity: Major
Iobenguane i and Isocarboxazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane enters cells via the norepinephrine transporter, and MAOIs may interfere with its uptake and retention and reduce its effectiveness. Labeling advises stopping interfering drugs before iobenguane administration.
What this interaction means in plain words
Iobenguane i and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Interference with catecholamine uptake and storage mechanisms reduces cellular uptake of iobenguane.
What to do
Discontinue isocarboxazid for at least five half-lives before iobenguane dosimetry or therapy, if clinically feasible. Do not resume until at least 7 days after each iobenguane dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Iobenguane i with Isocarboxazid?
MediHelp rates the interaction as major. Iobenguane i and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iobenguane enters cells via the norepinephrine transporter, and MAOIs may interfere with its uptake and retention and reduce its effectiveness. Labeling advises stopping interfering drugs before iobenguane administration.
How serious is the interaction between Iobenguane i and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discontinue isocarboxazid for at least five half-lives before iobenguane dosimetry or therapy, if clinically feasible. Do not resume until at least 7 days after each iobenguane dose.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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