Drug interactions
Iobenguane i + Phenelzine
Severity: Major
Iobenguane i and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane enters cells via the norepinephrine transporter. Drugs that block catecholamine uptake or deplete stores, including MAOIs, can reduce tumor uptake and so lessen diagnostic or therapeutic benefit.
What this interaction means in plain words
Iobenguane i and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Interference with catecholamine uptake or storage reduces cellular accumulation of radiolabeled iobenguane.
What to do
Stop phenelzine well before dosimetry or treatment, about five half-lives as per labeling, and withhold it for at least 7 days after each dose. Coordinate any change with the prescriber to manage the psychiatric condition meanwhile.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Iobenguane i with Phenelzine?
MediHelp rates the interaction as major. Iobenguane i and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iobenguane enters cells via the norepinephrine transporter. Drugs that block catecholamine uptake or deplete stores, including MAOIs, can reduce tumor uptake and so lessen diagnostic or therapeutic benefit.
How serious is the interaction between Iobenguane i and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop phenelzine well before dosimetry or treatment, about five half-lives as per labeling, and withhold it for at least 7 days after each dose. Coordinate any change with the prescriber to manage the psychiatric condition meanwhile.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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