Drug interactions
Iobenguane i + Pseudoephedrine
Severity: Moderate
Iobenguane i and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane is taken up into adrenergic neurons through the norepinephrine transporter, and sympathomimetics compete for this uptake. Pseudoephedrine may reduce tracer uptake and cause false-negative scans.
What this interaction means in plain words
Iobenguane i and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for the norepinephrine transporter reduces uptake of radiolabeled iobenguane into target tissue.
What to do
Withhold pseudoephedrine for several half-lives before iobenguane imaging, and follow the product labeling for the timing of restart after the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Iobenguane i with Pseudoephedrine?
MediHelp rates the interaction as moderate. Iobenguane i and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane is taken up into adrenergic neurons through the norepinephrine transporter, and sympathomimetics compete for this uptake. Pseudoephedrine may reduce tracer uptake and cause false-negative scans.
How serious is the interaction between Iobenguane i and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold pseudoephedrine for several half-lives before iobenguane imaging, and follow the product labeling for the timing of restart after the dose.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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