Drug interactions
Iobenguane i + Rasagiline
Severity: Moderate
Iobenguane i and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane uptake into cells depends on the norepinephrine transporter, and drugs that interfere with catecholamine uptake or storage may reduce its uptake and efficacy. Rasagiline is listed with such agents in labeling, although its effect is probably smaller than that of uptake inhibitors.
What this interaction means in plain words
Iobenguane i and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible interference with catecholamine uptake or storage reduces tumor uptake of iobenguane.
What to do
Hold rasagiline per the iobenguane labeling, for at least five half-lives before dosing, and do not restart until about 7 days after each dose, where clinically feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Iobenguane i with Rasagiline?
MediHelp rates the interaction as moderate. Iobenguane i and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane uptake into cells depends on the norepinephrine transporter, and drugs that interfere with catecholamine uptake or storage may reduce its uptake and efficacy. Rasagiline is listed with such agents in labeling, although its effect is probably smaller than that of uptake inhibitors.
How serious is the interaction between Iobenguane i and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold rasagiline per the iobenguane labeling, for at least five half-lives before dosing, and do not restart until about 7 days after each dose, where clinically feasible.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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