Drug interactions
Iobenguane i + Safinamide
Severity: Moderate
Iobenguane i and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs that interfere with catecholamine uptake or storage can reduce iobenguane uptake into target cells and lower its efficacy. The effect of MAO-B inhibitors on iobenguane is not clearly established, but labeling lists them as interfering drugs.
What this interaction means in plain words
Iobenguane i and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible interference with norepinephrine transporter-mediated uptake of iobenguane; mechanism for MAO-B inhibitors is not well defined.
What to do
Follow iobenguane labeling by holding the interfering drug for at least 5 half-lives before dosing and for at least 7 days after each dose, if clinically feasible. Coordinate with the treating neurologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Iobenguane i with Safinamide?
MediHelp rates the interaction as moderate. Iobenguane i and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drugs that interfere with catecholamine uptake or storage can reduce iobenguane uptake into target cells and lower its efficacy. The effect of MAO-B inhibitors on iobenguane is not clearly established, but labeling lists them as interfering drugs.
How serious is the interaction between Iobenguane i and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow iobenguane labeling by holding the interfering drug for at least 5 half-lives before dosing and for at least 7 days after each dose, if clinically feasible. Coordinate with the treating neurologist.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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