Drug interactions
Iobenguane i + Selegiline
Severity: Moderate
Iobenguane i and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane enters cells through the norepinephrine transporter. Drugs that interfere with catecholamine uptake or storage may reduce its uptake in target tissue and weaken its imaging or therapeutic effect. Selegiline is listed among agents potentially affecting this.
What this interaction means in plain words
Iobenguane i and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interference with catecholamine handling and uptake that reduces iobenguane accumulation in target cells.
What to do
Where clinically feasible, withhold selegiline for several half-lives before iobenguane administration and for at least 7 days after each dose, following the product labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Iobenguane i with Selegiline?
MediHelp rates the interaction as moderate. Iobenguane i and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane enters cells through the norepinephrine transporter. Drugs that interfere with catecholamine uptake or storage may reduce its uptake in target tissue and weaken its imaging or therapeutic effect. Selegiline is listed among agents potentially affecting this.
How serious is the interaction between Iobenguane i and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically feasible, withhold selegiline for several half-lives before iobenguane administration and for at least 7 days after each dose, following the product labeling.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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