Drug interactions
Iobenguane i + Timolol
Severity: Minor
Iobenguane i and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs that interfere with catecholamine uptake or stores may reduce uptake of iobenguane into target cells and weaken its diagnostic or therapeutic effect. Beta-blockers are not classic uptake inhibitors, so the evidence for timolol is limited. The concern is based on the iobenguane labeling class warning.
What this interaction means in plain words
Iobenguane i and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible interference with norepinephrine transporter-mediated uptake of iobenguane; not well established for timolol.
What to do
Review whether timolol is needed around iobenguane dosing and follow the product labeling on washout intervals for interfering drugs. Consult nuclear medicine before proceeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Frequently asked questions
Can I take Iobenguane i with Timolol?
MediHelp rates the interaction as minor. Iobenguane i and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs that interfere with catecholamine uptake or stores may reduce uptake of iobenguane into target cells and weaken its diagnostic or therapeutic effect. Beta-blockers are not classic uptake inhibitors, so the evidence for timolol is limited. The concern is based on the iobenguane labeling class warning.
How serious is the interaction between Iobenguane i and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether timolol is needed around iobenguane dosing and follow the product labeling on washout intervals for interfering drugs. Consult nuclear medicine before proceeding.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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