Drug interactions
Iodinated glycerol + Methimazole
Severity: Moderate
Iodinated glycerol and Methimazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated glycerol is an iodine-containing expectorant that delivers iodide systemically. Iodide can alter thyroid function and may add to or interfere with antithyroid therapy, with possible goiter or hypothyroidism.
What this interaction means in plain words
Iodinated glycerol and Methimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Iodide load affects thyroid hormone synthesis and release, producing additive thyroid suppression.
What to do
Avoid iodine-containing expectorants where possible, and monitor TSH and free T4 if they are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methimazole
- Carbamazepine + Methimazole Major
- Clozapine + Methimazole Major
- Methimazole + Propylthiouracil Major
- Methimazole + Sodium iodide i-131 Major
- Iodine + Methimazole Moderate
- Lycopus + Methimazole Moderate
Frequently asked questions
Can I take Iodinated glycerol with Methimazole?
MediHelp rates the interaction as moderate. Iodinated glycerol and Methimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated glycerol is an iodine-containing expectorant that delivers iodide systemically. Iodide can alter thyroid function and may add to or interfere with antithyroid therapy, with possible goiter or hypothyroidism.
How serious is the interaction between Iodinated glycerol and Methimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid iodine-containing expectorants where possible, and monitor TSH and free T4 if they are used.
What other medicines interact with Methimazole?
MediHelp also lists interactions of Methimazole with, for example, Carbamazepine, Clozapine, Propylthiouracil. The full list is on the Methimazole page.
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