Drug interactions
Iodinated glycerol + Spironolactone
Severity: Minor
Iodinated glycerol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodide-containing products can cause hyperkalemia in some patients, and combining with spironolactone could add to potassium retention. The effect is mostly reported with iodide and is likely small, but matters in renal impairment.
What this interaction means in plain words
Iodinated glycerol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Iodide may impair renal potassium handling, adding to the potassium-retaining effect of aldosterone antagonism; the mechanism is not fully established.
What to do
Monitor serum potassium if used together long term, particularly in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Iodinated glycerol with Spironolactone?
MediHelp rates the interaction as minor. Iodinated glycerol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iodide-containing products can cause hyperkalemia in some patients, and combining with spironolactone could add to potassium retention. The effect is mostly reported with iodide and is likely small, but matters in renal impairment.
How serious is the interaction between Iodinated glycerol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if used together long term, particularly in patients with renal impairment.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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