Drug interactions
Ioflupane i + Paroxetine
Severity: Minor
Ioflupane i and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine bind the serotonin transporter, which contributes to ioflupane uptake in some brain regions. This could alter the image, although striatal dopamine transporter imaging is mainly affected by dopamine transporter ligands.
What this interaction means in plain words
Ioflupane i and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition at monoamine transporter binding sites that may alter tracer uptake.
What to do
Be aware of possible image interference when interpreting the scan. Seek nuclear medicine advice on whether to withhold paroxetine before imaging; do not stop it without clinical review.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Ioflupane i with Paroxetine?
MediHelp rates the interaction as minor. Ioflupane i and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as paroxetine bind the serotonin transporter, which contributes to ioflupane uptake in some brain regions. This could alter the image, although striatal dopamine transporter imaging is mainly affected by dopamine transporter ligands.
How serious is the interaction between Ioflupane i and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of possible image interference when interpreting the scan. Seek nuclear medicine advice on whether to withhold paroxetine before imaging; do not stop it without clinical review.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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