Drug interactions
Ioversol + Rituximab
Severity: Minor
Ioversol and Rituximab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rituximab can cause tumor lysis and infusion reactions that affect kidney function, and iodinated contrast can cause contrast nephropathy. Combined exposure may add to kidney injury risk, but a direct interaction is not well established.
What this interaction means in plain words
Ioversol and Rituximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive nephrotoxic risk; no established direct pharmacokinetic mechanism.
What to do
Ensure adequate hydration and monitor serum creatinine around contrast exposure in patients receiving rituximab, especially with high tumor burden.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rituximab
Frequently asked questions
Can I take Ioversol with Rituximab?
MediHelp rates the interaction as minor. Ioversol and Rituximab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rituximab can cause tumor lysis and infusion reactions that affect kidney function, and iodinated contrast can cause contrast nephropathy. Combined exposure may add to kidney injury risk, but a direct interaction is not well established.
How serious is the interaction between Ioversol and Rituximab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine around contrast exposure in patients receiving rituximab, especially with high tumor burden.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
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