Drug interactions
Ioversol + Streptomycin
Severity: Moderate
Ioversol and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iodinated contrast can cause acute kidney injury, and streptomycin is itself nephrotoxic and ototoxic. Given together, the risk of renal impairment rises, and reduced renal function leads to streptomycin accumulation and greater ototoxicity and vestibular toxicity.
What this interaction means in plain words
Ioversol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with secondary accumulation of renally cleared streptomycin increasing ototoxic risk.
What to do
Ensure adequate hydration and check serum creatinine before and after contrast exposure. Delay nonurgent streptomycin dosing or adjust the dose and monitor levels if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Streptomycin
Frequently asked questions
Can I take Ioversol with Streptomycin?
MediHelp rates the interaction as moderate. Ioversol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iodinated contrast can cause acute kidney injury, and streptomycin is itself nephrotoxic and ototoxic. Given together, the risk of renal impairment rises, and reduced renal function leads to streptomycin accumulation and greater ototoxicity and vestibular toxicity.
How serious is the interaction between Ioversol and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check serum creatinine before and after contrast exposure. Delay nonurgent streptomycin dosing or adjust the dose and monitor levels if renal function declines.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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