Drug interactions
Irinotecan + Ofatumumab sc
Severity: Moderate
Irinotecan and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and irinotecan causes myelosuppression, so together they may raise infection risk. Ofatumumab SC (Kesimpta) is used for multiple sclerosis, making this combination uncommon.
What this interaction means in plain words
Irinotecan and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and chemotherapy-induced myelosuppression.
What to do
Monitor for infection and neutrophil counts, and review the need for ofatumumab during chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Ofatumumab sc?
MediHelp rates the interaction as moderate. Irinotecan and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and irinotecan causes myelosuppression, so together they may raise infection risk. Ofatumumab SC (Kesimpta) is used for multiple sclerosis, making this combination uncommon.
How serious is the interaction between Irinotecan and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and neutrophil counts, and review the need for ofatumumab during chemotherapy.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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