Drug interactions
Irinotecan + Ponatinib
Severity: Moderate
Irinotecan and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-gp and BCRP, transporters handling irinotecan and SN-38, and may increase exposure. Both drugs can cause myelosuppression and gastrointestinal toxicity. Clinical data are limited.
What this interaction means in plain words
Irinotecan and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Ponatinib belongs to Oncology.
Why it happens
Ponatinib inhibits P-gp and BCRP efflux transporters.
What to do
Monitor blood counts and diarrhea, and reduce irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Irinotecan with Ponatinib?
MediHelp rates the interaction as moderate. Irinotecan and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits P-gp and BCRP, transporters handling irinotecan and SN-38, and may increase exposure. Both drugs can cause myelosuppression and gastrointestinal toxicity. Clinical data are limited.
How serious is the interaction between Irinotecan and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea, and reduce irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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