Drug interactions
Irinotecan + Sipuleucel-t
Severity: Moderate
Irinotecan and Sipuleucel-t: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy with immunosuppressive effects could theoretically blunt the immune response sipuleucel-T is meant to produce. The labeling advises considering this when used with immunosuppressants.
What this interaction means in plain words
Irinotecan and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic myelosuppression and immunosuppression may reduce the immune cell activation on which sipuleucel-T depends.
What to do
Avoid giving chemotherapy around leukapheresis and infusion where possible, and discuss sequencing with the oncology team.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Sipuleucel-t?
MediHelp rates the interaction as moderate. Irinotecan and Sipuleucel-t can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy with immunosuppressive effects could theoretically blunt the immune response sipuleucel-T is meant to produce. The labeling advises considering this when used with immunosuppressants.
How serious is the interaction between Irinotecan and Sipuleucel-t?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving chemotherapy around leukapheresis and infusion where possible, and discuss sequencing with the oncology team.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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