Drug interactions
Irinotecan + Tesamorelin
Severity: Minor
Irinotecan and Tesamorelin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tesamorelin raises growth hormone and IGF-1, and these hormones can alter the activity of some CYP enzymes, including CYP3A4. Irinotecan is activated and cleared in part by CYP3A4, so the clinical effect is unpredictable. No well-documented clinical interaction exists.
What this interaction means in plain words
Irinotecan and Tesamorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical change in CYP3A4 activity through growth hormone axis effects; not clearly established.
What to do
No routine adjustment is needed. Monitor for irinotecan toxicity (diarrhea, neutropenia) and for reduced response during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Irinotecan with Tesamorelin?
MediHelp rates the interaction as minor. Irinotecan and Tesamorelin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tesamorelin raises growth hormone and IGF-1, and these hormones can alter the activity of some CYP enzymes, including CYP3A4. Irinotecan is activated and cleared in part by CYP3A4, so the clinical effect is unpredictable. No well-documented clinical interaction exists.
How serious is the interaction between Irinotecan and Tesamorelin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for irinotecan toxicity (diarrhea, neutropenia) and for reduced response during therapy.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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