Drug interactions
Irinotecan liposomal + Netupitant-palonosetron
Severity: Moderate
Irinotecan liposomal and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Netupitant may raise exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4, potentially increasing neutropenia and diarrhea. Netupitant/palonosetron is often used with irinotecan-based chemotherapy, and clinical impact appears limited.
What this interaction means in plain words
Irinotecan liposomal and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Netupitant inhibits CYP3A4, which can alter irinotecan metabolism.
What to do
Monitor for neutropenia and diarrhea during treatment cycles with the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Irinotecan liposomal and Netupitant-palonosetron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Frequently asked questions
Can I take Irinotecan liposomal with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Netupitant may raise exposure to irinotecan and its active metabolite SN-38 by inhibiting CYP3A4, potentially increasing neutropenia and diarrhea. Netupitant/palonosetron is often used with irinotecan-based chemotherapy, and clinical impact appears limited.
How serious is the interaction between Irinotecan liposomal and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neutropenia and diarrhea during treatment cycles with the combination.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
