Drug interactions
Irinotecan liposomal + Nilotinib
Severity: Moderate
Irinotecan liposomal and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and UGT1A1, which may increase exposure to irinotecan and its active metabolite SN-38. This may worsen neutropenia and diarrhea, though liposomal formulation alters disposition.
What this interaction means in plain words
Irinotecan liposomal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nilotinib inhibits P-glycoprotein efflux and UGT1A1-mediated SN-38 glucuronidation.
What to do
Monitor blood counts and diarrhea, and reduce the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Nilotinib?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and UGT1A1, which may increase exposure to irinotecan and its active metabolite SN-38. This may worsen neutropenia and diarrhea, though liposomal formulation alters disposition.
How serious is the interaction between Irinotecan liposomal and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and diarrhea, and reduce the irinotecan dose if toxicity develops.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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