Drug interactions
Irinotecan liposomal + Oxcarbazepine
Severity: Moderate
Irinotecan liposomal and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower exposure to irinotecan and its active metabolite SN-38 through CYP3A4 induction. This could reduce antitumor efficacy. Strong inducers are the main concern in labeling, and oxcarbazepine is weaker.
What this interaction means in plain words
Irinotecan liposomal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction diverts irinotecan to inactive oxidative metabolites, reducing SN-38 formation and exposure.
What to do
Prefer a non-enzyme-inducing anticonvulsant where possible, and monitor tumor response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Irinotecan liposomal with Oxcarbazepine?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may lower exposure to irinotecan and its active metabolite SN-38 through CYP3A4 induction. This could reduce antitumor efficacy. Strong inducers are the main concern in labeling, and oxcarbazepine is weaker.
How serious is the interaction between Irinotecan liposomal and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-enzyme-inducing anticonvulsant where possible, and monitor tumor response and toxicity.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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