Drug interactions
Irinotecan liposomal + Sorafenib
Severity: Moderate
Irinotecan liposomal and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib inhibits UGT1A1, the enzyme that glucuronidates SN-38, the active metabolite of irinotecan. Higher SN-38 exposure can worsen neutropenia and diarrhea.
What this interaction means in plain words
Irinotecan liposomal and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sorafenib inhibits UGT1A1-mediated glucuronidation of SN-38, reducing its clearance.
What to do
Monitor blood counts and watch for severe diarrhea during combined use. Reduce the irinotecan dose or interrupt treatment if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Frequently asked questions
Can I take Irinotecan liposomal with Sorafenib?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib inhibits UGT1A1, the enzyme that glucuronidates SN-38, the active metabolite of irinotecan. Higher SN-38 exposure can worsen neutropenia and diarrhea.
How serious is the interaction between Irinotecan liposomal and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and watch for severe diarrhea during combined use. Reduce the irinotecan dose or interrupt treatment if toxicity develops.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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