Drug interactions
Irinotecan liposomal + Tolvaptan
Severity: Minor
Irinotecan liposomal and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-gp in vitro, which could theoretically increase irinotecan exposure. Liposomal formulation alters distribution, and clinical significance is uncertain.
What this interaction means in plain words
Irinotecan liposomal and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical P-gp inhibition by tolvaptan may reduce irinotecan efflux.
What to do
Monitor for irinotecan toxicity such as diarrhea and neutropenia. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Irinotecan liposomal with Tolvaptan?
MediHelp rates the interaction as minor. Irinotecan liposomal and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-gp in vitro, which could theoretically increase irinotecan exposure. Liposomal formulation alters distribution, and clinical significance is uncertain.
How serious is the interaction between Irinotecan liposomal and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for irinotecan toxicity such as diarrhea and neutropenia. No routine dose change is needed.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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