Drug interactions
Irinotecan liposomal + Trastuzumab
Severity: Moderate
Irinotecan liposomal and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liposomal irinotecan frequently causes severe neutropenia, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia and febrile neutropenia. Infection risk may be higher with both.
What this interaction means in plain words
Irinotecan liposomal and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression, mainly from irinotecan's topoisomerase I inhibition in hematopoietic cells.
What to do
Monitor complete blood counts before each cycle and for fever or infection. Withhold or reduce liposomal irinotecan for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Irinotecan liposomal with Trastuzumab?
MediHelp rates the interaction as moderate. Irinotecan liposomal and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liposomal irinotecan frequently causes severe neutropenia, and trastuzumab with myelosuppressive therapy has been linked to more neutropenia and febrile neutropenia. Infection risk may be higher with both.
How serious is the interaction between Irinotecan liposomal and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and for fever or infection. Withhold or reduce liposomal irinotecan for significant neutropenia.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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