Drug interactions
Iron + Lansoprazole
Severity: Moderate
Iron and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lansoprazole suppresses gastric acid, and oral iron salts depend on an acidic environment to dissolve and be absorbed. Long-term use can reduce iron uptake and may blunt the response to iron replacement.
What this interaction means in plain words
Iron and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH reduces solubility and reduction of ferric iron to the absorbable ferrous form.
What to do
Monitor hemoglobin and ferritin in patients on oral iron with long-term PPI therapy. Consider the lowest effective PPI dose or parenteral iron if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Frequently asked questions
Can I take Iron with Lansoprazole?
MediHelp rates the interaction as moderate. Iron and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lansoprazole suppresses gastric acid, and oral iron salts depend on an acidic environment to dissolve and be absorbed. Long-term use can reduce iron uptake and may blunt the response to iron replacement.
How serious is the interaction between Iron and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin in patients on oral iron with long-term PPI therapy. Consider the lowest effective PPI dose or parenteral iron if response is inadequate.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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