Drug interactions
Iron + Rabeprazole
Severity: Moderate
Iron and Rabeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rabeprazole lowers gastric acid, which can reduce absorption of oral iron. Long-term use may weaken the response to iron supplementation.
What this interaction means in plain words
Iron and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Iron belongs to Gastrointestinal Tract; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH decreases iron solubility and reduction to the ferrous form.
What to do
Monitor hemoglobin and ferritin in patients on prolonged co-therapy. Consider the lowest effective PPI dose or parenteral iron if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Iron with Rabeprazole?
MediHelp rates the interaction as moderate. Iron and Rabeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rabeprazole lowers gastric acid, which can reduce absorption of oral iron. Long-term use may weaken the response to iron supplementation.
How serious is the interaction between Iron and Rabeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin in patients on prolonged co-therapy. Consider the lowest effective PPI dose or parenteral iron if response is inadequate.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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