Drug interactions
Isocarboxazid + Lorcaserin
Severity: Major
Isocarboxazid and Lorcaserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and using it with an MAOI raises the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity.
What this interaction means in plain words
Isocarboxazid and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects from MAO inhibition (reduced serotonin breakdown) together with direct 5-HT2C receptor agonism.
What to do
Avoid concurrent use; allow a washout of at least 14 days after stopping the MAOI before starting lorcaserin. Select an alternative weight-management approach.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Lorcaserin?
MediHelp rates the interaction as major. Isocarboxazid and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist, and using it with an MAOI raises the risk of serotonin syndrome. Features include agitation, tremor, hyperthermia, autonomic instability and neuromuscular hyperactivity.
How serious is the interaction between Isocarboxazid and Lorcaserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; allow a washout of at least 14 days after stopping the MAOI before starting lorcaserin. Select an alternative weight-management approach.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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