Drug interactions
Isocarboxazid + Lsd
Severity: Major
Isocarboxazid and Lsd: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonergic agonist, and an MAOI may intensify and prolong its effects. This can lead to serotonin toxicity, severe hallucinations, hypertension, hyperthermia and agitation.
What this interaction means in plain words
Isocarboxazid and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic stimulation: MAO inhibition raises synaptic monoamines while LSD directly activates 5-HT2A and other serotonin receptors.
What to do
Avoid the combination; counsel patients on MAOIs against use of hallucinogens. Treat suspected toxicity with supportive care, benzodiazepines and cooling, and stop serotonergic agents.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Lsd?
MediHelp rates the interaction as major. Isocarboxazid and Lsd can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. LSD is a potent serotonergic agonist, and an MAOI may intensify and prolong its effects. This can lead to serotonin toxicity, severe hallucinations, hypertension, hyperthermia and agitation.
How serious is the interaction between Isocarboxazid and Lsd?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; counsel patients on MAOIs against use of hallucinogens. Treat suspected toxicity with supportive care, benzodiazepines and cooling, and stop serotonergic agents.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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