Drug interactions
Isocarboxazid + Metformin-sitagliptin
Severity: Moderate
Isocarboxazid and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The effect is more pronounced with insulin and sulfonylureas than with metformin or sitagliptin.
What this interaction means in plain words
Isocarboxazid and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isocarboxazid belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
MAO inhibition may increase insulin sensitivity and stimulate insulin secretion, adding to the glucose-lowering effect.
What to do
Monitor blood glucose when isocarboxazid is started or stopped and reduce antidiabetic doses if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Isocarboxazid and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can enhance the glucose-lowering effect of antidiabetic drugs and have been associated with hypoglycemia. The effect is more pronounced with insulin and sulfonylureas than with metformin or sitagliptin.
How serious is the interaction between Isocarboxazid and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when isocarboxazid is started or stopped and reduce antidiabetic doses if hypoglycemia develops.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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