Drug interactions
Isocarboxazid + Methyclothiazide
Severity: Moderate
Isocarboxazid and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and isocarboxazid can cause orthostatic hypotension. Together they may produce excessive hypotension, dizziness and falls.
What this interaction means in plain words
Isocarboxazid and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from diuretic-induced volume depletion and MAOI-related orthostatic hypotension.
What to do
Monitor blood pressure including standing readings, and reduce the diuretic dose if symptomatic hypotension occurs. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Methyclothiazide?
MediHelp rates the interaction as moderate. Isocarboxazid and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and isocarboxazid can cause orthostatic hypotension. Together they may produce excessive hypotension, dizziness and falls.
How serious is the interaction between Isocarboxazid and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings, and reduce the diuretic dose if symptomatic hypotension occurs. Counsel patients to rise slowly.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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