Drug interactions
Isocarboxazid + Netupitant / palonosetron
Severity: Moderate
Isocarboxazid and Netupitant / palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported when drugs of this class are given with serotonergic agents. Taken with an MAOI, the risk of serotonin toxicity may be increased, with agitation, hyperthermia and neuromuscular signs.
What this interaction means in plain words
Isocarboxazid and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; the mechanism for 5-HT3 antagonists is not clearly established.
What to do
Monitor for mental status changes, autonomic instability and neuromuscular signs when used together, and stop the antiemetic if serotonin syndrome is suspected. Consider an alternative antiemetic if the MAOI cannot be interrupted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Netupitant / palonosetron?
MediHelp rates the interaction as moderate. Isocarboxazid and Netupitant / palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palonosetron is a 5-HT3 antagonist, and serotonin syndrome has been reported when drugs of this class are given with serotonergic agents. Taken with an MAOI, the risk of serotonin toxicity may be increased, with agitation, hyperthermia and neuromuscular signs.
How serious is the interaction between Isocarboxazid and Netupitant / palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status changes, autonomic instability and neuromuscular signs when used together, and stop the antiemetic if serotonin syndrome is suspected. Consider an alternative antiemetic if the MAOI cannot be interrupted.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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